97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
超碰夜色,japanese护士高潮,动漫美女被免费网站
Rabbit Anti-GATA4/AP Conjugated antibody (bs-23982R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-23982R-AP
英文名稱 Rabbit Anti-GATA4/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的GATA結(jié)合蛋白4抗體
別    名 GATA binding factor 4; GATA 4; GATA4; GATA-4; Transcription factor GATA-4; GATA-binding factor 4; Gata4; GATA4_HUMAN; GATA-binding factor 4.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  發(fā)育生物學(xué)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GATA4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs.

Function:
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.

Subunit:
Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Subcellular Location:
Nucleus.

Post-translational modifications:
Methylation at Lys-300 attenuates transcriptional activity.

DISEASE:
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

Similarity:
Contains 2 GATA-type zinc fingers.

Database links:

Entrez Gene: 2626 Human

Entrez Gene: 14463 Mouse

Entrez Gene: 54254 Rat

Omim: 600576 Human

SwissProt: P43694 Human

SwissProt: Q08369 Mouse

SwissProt: P46152 Rat

Unigene: 243987 Human

Unigene: 247669 Mouse

Unigene: 26251 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GATA-4屬于轉(zhuǎn)錄調(diào)節(jié)性因子,表達(dá)在心組織、胃腸道組織中,并調(diào)節(jié)該類T細(xì)胞的發(fā)育和功能。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 国产一区二区四区在线观看 | 色欲久久久天天天综合影院 | 91精品一区二区三区综合在线爱 | 四虎影视免费在线 | 操操操操网 | CHINESEMATURE老女熟 | 天堂久久一区二区三区 | 国产精品欧美综合亚洲 | 人人射人人爽 | 国产亚洲精品一区二555 | 刺激性视频黄页 | 欧美xxxx做受欧美88 | 国产精品69久久久久孕妇欧美 | 欧美日本在线一区 | 免费A级毛片无码A∨中文字幕 | 狠狠干狠狠搞 | 国产欧美一区二区三区免费 | 69综合精品国产二区无码 | 亚无码乱人伦一区二区 | 国产真实一区二区三区 | 丰满老熟女毛片hd | 少妇仑乱A毛片 | 亚洲国产一区二区三区精品 | 久久九色 | 囯产精品一品二区三区 | 在线精品亚洲一区二区动态图 | 婷婷九月综合 | 国产内射老熟女aaaa | 欧美人与动牲交片免费播放 | 日韩精品无码一区二区中文字幕 | 99在线视频免费 | 国产高清一区在线观看 | 亚洲日韩欧美综合 | 人人妻人人爽人人做夜欢视频九色 | xxx2高清在线观看免费视频 | 日日天天 | 亚洲毛茸茸浓毛多水多 | 免费视频爱爱 | 欧美在线欧美在线 | 一本之道中文日本高清 | 久久久WWW成人免费毛片 |