97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
少妇的肉体AAAAA免费视频,中文字幕制服欧美久久一区,亚洲综合色区另类aⅴ
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-GATA4 /Gold Conjugated antibody (bs-23983R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-23983R-Gold
英文名稱 Rabbit Anti-GATA4 /Gold Conjugated antibody
中文名稱 膠體金標記的GATA結合蛋白4抗體
別    名 GATA binding factor 4; GATA 4; GATA4; GATA-4; Transcription factor GATA-4; GATA-binding factor 4; Gata4; GATA4_HUMAN; GATA-binding factor 4.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 心血管  免疫學  發育生物學  干細胞  轉錄調節因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GATA4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs.

Function:
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.

Subunit:
Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Subcellular Location:
Nucleus.

Post-translational modifications:
Methylation at Lys-300 attenuates transcriptional activity.

DISEASE:
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

Similarity:
Contains 2 GATA-type zinc fingers.

Database links:

Entrez Gene: 2626 Human

Entrez Gene: 14463 Mouse

Entrez Gene: 54254 Rat

Omim: 600576 Human

SwissProt: P43694 Human

SwissProt: Q08369 Mouse

SwissProt: P46152 Rat

Unigene: 243987 Human

Unigene: 247669 Mouse

Unigene: 26251 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GATA-4屬于轉錄調節性因子,表達在心組織、胃腸道組織中,并調節該類T細胞的發育和功能。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 欧美日韩国产人妻无码 | 9191视频| 午夜福利精品导航凹凸 | a免费在线观看 | 在线国产精品一区 | 亚洲乱码中文字幕小综合 | 在线观看国产中文字幕 | 婷婷成人基地 | 国产成人啪精品午夜网站a片免费 | 最近中文字幕免费MV在线视频 | 超碰热久久 | 婷婷丁香亚洲色综合91 | 波多老师无码av中字专区 | 日韩精品资源二区在线 | 九九婷婷 | 阿公抱着我边摸边吃奶视频 | 一区二区三区四区免费在线观看 | 一本到不卡免费一区二区 | 久久久99精品免费观看乱色 | 一区二区免费在线观看 | 边摸边吃奶边做爰视频网站 | 色日韩综合 | 精品欧美不卡一区二区在线观看 | 一级黄色特级片 | 性色AV一区二区三区V视界影院 | 无码专区—va亚洲v专区 | 69精产国品一二三产品价格 | 国产吹潮视频在线观看 | 亚色九九九全国免费视频 | 亚洲AⅤ人片在线观看无 | 无码一区自拍偷拍第二页 | 国产精品久久人妻无码网站 | 永久免费无码国产 | 久久婷婷人人澡人人爽人人爱 | 女人黄色毛片 | 久久精品国产亚洲av麻豆小说 | 中文字幕日韩网站免费视频 | 亚洲午夜精品久久久久久高潮 | 国产h视频在线 | 一级二级三级毛片 | 免费性色|