97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
2024国产在线,丝袜国产在线观看,人人爱人人插
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-GATA4 /BF350 Conjugated antibody (bs-23983R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-23983R-BF350
英文名稱 Rabbit Anti-GATA4 /BF350 Conjugated antibody
中文名稱 BF350標記的GATA結合蛋白4抗體
別    名 GATA binding factor 4; GATA 4; GATA4; GATA-4; Transcription factor GATA-4; GATA-binding factor 4; Gata4; GATA4_HUMAN; GATA-binding factor 4.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  免疫學  發(fā)育生物學  干細胞  轉錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Rabbit, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GATA4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs.

Function:
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.

Subunit:
Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Subcellular Location:
Nucleus.

Post-translational modifications:
Methylation at Lys-300 attenuates transcriptional activity.

DISEASE:
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

Similarity:
Contains 2 GATA-type zinc fingers.

Database links:

Entrez Gene: 2626 Human

Entrez Gene: 14463 Mouse

Entrez Gene: 54254 Rat

Omim: 600576 Human

SwissProt: P43694 Human

SwissProt: Q08369 Mouse

SwissProt: P46152 Rat

Unigene: 243987 Human

Unigene: 247669 Mouse

Unigene: 26251 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GATA-4屬于轉錄調(diào)節(jié)性因子,表達在心組織、胃腸道組織中,并調(diào)節(jié)該類T細胞的發(fā)育和功能。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 91免费网| 亚洲国产精品国自产拍久久 | www.色姐姐 | 中日字幕大片在线播放 | 国产成人综合自拍 | 东京热亚洲精品中文一区 | 飘雪影院免费版在线观看视频 | 久草麻豆 | 97精品在线观看 | 第一区在线观看免费国语入口 | 人妻夫の上司犯感との中文字幕 | 欧美午夜精品一区二区蜜桃 | 欧美二三区| 国产一区二区不卡在线 | www.精品一区 | 国产免费永久在线观看 | 国产精品视频麻豆 | 久久中文字幕亚洲 | 日本少妇高潮叫床声 | 国产大BBWBBWHD视频 | 一本一本久久A久久综合精品蜜桃 | 久久艹一区 | 国产精品视频xxx | 大地资源在线观看视频 | a免费在线观看 | 绿巨人在线观看免费观看在线nba动漫 | 99热色 | 我要看免费的黄色片 | 亚洲综合色丁香婷婷六月图片 | 欧美肥妇毛多水多bbxx水蜜桃 | 乱60一70归性欧老妇 | 亚洲第一黄色网址 | GOGOGO免费高清视频3 | 免费人成视频网站在线18 | 欧美色插| 欧美日韩一区二区国产 | 天天综合网页在线观看 | 8050一级毛片 | 亚洲色欲色欲综合网站 | 1769在线视频 | 亚洲一级网|