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Rabbit Anti-FBXO18 /BF488 Conjugated antibody (bs-10496R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-10496R-BF488
英文名稱 Rabbit Anti-FBXO18 /BF488 Conjugated antibody
中文名稱 BF488標記的 F-box蛋白家族FBXO18抗體
別    名 Fbx18; FLJ14590; MGC131916; MGC141935; MGC141937; F box DNA helicase 1; F box only protein 18; F box protein, helicase, 18; F-box only protein 18, F-box DNA helicase 1; FBH1; FBX18_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Horse, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 118kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FBXO18
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
FBXO18 belongs to the F-box protein family, whose members share the F-box, an approximately 40 amino acid motif. It has both DNA-dependent ATPase and DNA unwinding activities.
FBXO18 is a 1,043 amino acid protein encoded by the human gene FBXO18. FBXO18 belongs to the helicase family (UvrD subfamily) and contains one F-box domain. This nuclear protein is a DNA-dependent ATPase that unwinds double-stranded DNA in a 3' to 5' direction. FBXO18 also recognizes and binds to a variety of phosphorylated proteins and promotes their ubiquitination and degradation. It also interacts with Skp1 in the SCF E3 ubiquitin ligase complex consisting of Skp1, CUL-1, Rbx1 and FBXO18.

Function:
DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction.
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Subunit:
Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1.

Subcellular Location:
Nuclear

Similarity:
Belongs to the helicase family. UvrD subfamily.
Contains 1 F-box domain.

Database links:

Entrez Gene: 84893 Human

GenBank: BC113377 Human

Omim: 607222 Human

SwissProt: Q8NFZ0 Human

Unigene: 498543 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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