97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
国产乱色国产精品免费视频,日本色日夜干,91大神在线免费观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-TRPV1/AP Conjugated antibody (bs-23926R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-23926R-AP
英文名稱 Rabbit Anti-TRPV1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的辣椒素受體抗體
別    名 Capsaicin receptor; DKFZp434K0220; Osm 9 like TRP channel 1; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; TRPV 1; TRPV1; Vanilloid receptor 1; Vanilloid receptor subtype 1; VR 1; VR1; TRPV1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  免疫學  細胞凋亡  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPV1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke a perception of pain which initiates appropriate protective reflexes. The receptor for capsaicin, VR1 (vanilloid receptor 1; TRPV1 is a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels. The vanilloid receptor 1 protein functions both as a receptor for capsaicin and a transducter of noxious thermal stimuli. VR1 protein is localized to small-diameter sensory neurons within the dorsal root ganglia and nerve terminals in the dorsal horn.

Function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons.

Subunit:
Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex.

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendritic spine membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).

Post-translational modifications:
Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
Contains 6 ANK repeats.

Database links:

Entrez Gene: 7442 Human

Entrez Gene: 193034 Mouse

Entrez Gene: 83810 Rat

Omim: 602076 Human

SwissProt: Q8NER1 Human

SwissProt: Q704Y3 Mouse

SwissProt: O35433 Rat

Unigene: 579217 Human

Unigene: 655380 Human

Unigene: 447485 Mouse

Unigene: 3073 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

辣椒素受體(Vanilloid receptor subtype 1)是機體的一個重要的損傷性感受蛋白,參與了多種生理活動和病理過程,起到對中樞和外周水平疼痛的形成,還可以激活神經纖維末端的辣椒素受體,調節(jié)外周血管的舒縮,影響血壓,對缺血心肌起到保護作用; VR1還參與哮喘的發(fā)生,調節(jié)胃酸的分泌,促進胃腸蠕動。另外,激活辣椒素受體,還可抑制毛干的增殖,近年來發(fā)現(xiàn)他介導腫瘤細胞的凋亡。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产成人毛片 | 国产成年无码久久久免费 | 99国精视频一区一区一三 | 国产欧美一级 | 亚洲影院丰满少妇中文字幕无码 | 人妻人人澡人人添人人爽 | 一级全黄男女免费大片 | 久久久久久国产精品无码超碰 | 国产精品99久久久久久小说 | 4399午夜理伦免费播放大全 | 日本波多野结衣在线 | 亚洲成人生活片 | 免费精品国产福利片 | 亚洲综合视频在线播放 | 免费观看一级特黄欧美大片 | 永久亚洲成a人片777777 | 久久精品国产亚洲av麻豆小说 | 久久爱黑人激情av | 国外精品久久久蜜桃免费全文阅读 | 在线亚洲无砖砖区免费 | Chinese国产HD精品实拍 | 国产aⅴ无码久久久高潮老头 | 亚洲精品无码一区二区三区污 | 国产做爰全免费的视频软件 | 国产成人愉拍精品 | 国产成人啪精品午夜网站a片免费 | 日韩AV无码社区一区二区三区 | 91亚洲国产成人久久精品麻豆 | 我的妺妺h伦浴室无码视频 国产激情无码视频在线播放性色 | sese综合| 婷婷亚洲综合小说图片 | 亚洲韩国欧洲国产日产av | 在线观看特色大片免费视频 | 真人在线观看色网视频 | 啦啦啦啦WWW日本在线观看 | 男人女人做爽爽18禁免费 | 国产第二区国产一级片播放 | 91精品国产综合久久久久久丝袜 | 国产亚洲视频网站 | 日韩视频一区尤物少妇偷拍 | 亚洲精品亚洲人成在线观看 |