97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
免费黄网站在线播放,日韩动漫av,欧美久久久久久久久中文字幕
Rabbit Anti-TRPV1/BF647 Conjugated antibody (bs-23926R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-23926R-BF647
英文名稱 Rabbit Anti-TRPV1/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的辣椒素受體抗體
別    名 Capsaicin receptor; DKFZp434K0220; Osm 9 like TRP channel 1; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; TRPV 1; TRPV1; Vanilloid receptor 1; Vanilloid receptor subtype 1; VR 1; VR1; TRPV1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  細(xì)胞凋亡  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPV1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke a perception of pain which initiates appropriate protective reflexes. The receptor for capsaicin, VR1 (vanilloid receptor 1; TRPV1 is a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels. The vanilloid receptor 1 protein functions both as a receptor for capsaicin and a transducter of noxious thermal stimuli. VR1 protein is localized to small-diameter sensory neurons within the dorsal root ganglia and nerve terminals in the dorsal horn.

Function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons.

Subunit:
Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex.

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendritic spine membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).

Post-translational modifications:
Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
Contains 6 ANK repeats.

Database links:

Entrez Gene: 7442 Human

Entrez Gene: 193034 Mouse

Entrez Gene: 83810 Rat

Omim: 602076 Human

SwissProt: Q8NER1 Human

SwissProt: Q704Y3 Mouse

SwissProt: O35433 Rat

Unigene: 579217 Human

Unigene: 655380 Human

Unigene: 447485 Mouse

Unigene: 3073 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

辣椒素受體(Vanilloid receptor subtype 1)是機(jī)體的一個重要的損傷性感受蛋白,參與了多種生理活動和病理過程,起到對中樞和外周水平疼痛的形成,還可以激活神經(jīng)纖維末端的辣椒素受體,調(diào)節(jié)外周血管的舒縮,影響血壓,對缺血心肌起到保護(hù)作用; VR1還參與哮喘的發(fā)生,調(diào)節(jié)胃酸的分泌,促進(jìn)胃腸蠕動。另外,激活辣椒素受體,還可抑制毛干的增殖,近年來發(fā)現(xiàn)他介導(dǎo)腫瘤細(xì)胞的凋亡。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 亚洲欧美日韩精品成人 | 国产一区二区三区四区五区加勒比 | 一区二区三区四区乱码 | 国产欧美一区二区三区视频 | 欧美成人一区二区在线观看 | 国产成人8x人网站视频 | 欧美性受ⅹ╳╳╳黑人a性爽 | 国产精品二区在线 | 欧美熟妇bb | 黑人巨大精品一区二区 | 国产裸体舞一区二区三区 | 无码人妻一区二区三区AV | 黄色录像久久 | 亚洲女同成av人片在线观看 | 97人伦影院A级毛片 操操网址 | 久久99日韩国产精品久久99 | 麻豆国产手机福利看片 | 久热综合网 | 被黑人伦流澡到高潮hn小说 | 欧美成人一区二区在线观看 | 飘雪影院免费版在线观看视频 | 色老板精品视频在线观看 | 午夜精品久久久久9999高清 | 一级做性色a爰片久久毛片免费 | 国产精品成人亚洲一区二区 | 林雅诗三级无删减在线观看 | 久久久久久久久艹 | 国产国拍亚洲精品在线 | 她似遥上月短剧免费观看 | 国产成人无码a区精油按摩 大地资源在线观看免费高清官网 | 麻豆视频观看免费视频观看 | 9久9久女女热精品视频在线观看 | 久久77 | 中文字幕97在线 | 免费一级好看的国产 | 久久综合香蕉国产蜜臀av | 欧美一区二区三区久久精品视 | 亚洲色炮av图 | 国产精品久久久久久婷婷动漫 | 国产一区久久久 | 国产午夜亚洲精品 |