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Mouse Anti-LOX/Gold Conjugated antibody (bsm-51207M-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bsm-51207M-Gold
英文名稱 Mouse Anti-LOX/Gold Conjugated antibody
中文名稱 膠體金標記的小鼠抗蛋白賴氨酸-6-氧化酶單克隆抗體
別    名 lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 4C3
交叉反應 (predicted: Human, Mouse, Rat, Pig, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LOX
亞    型 IgG2b
純化方法 affinity purified by Protein G
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Function:
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.

Subcellular Location:
Secreted; extracellular space

Tissue Specificity:
Heart, placenta, skeletal muscle, kidney, lung and pancreas.

Post-translational modifications:
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Proteolytically activated by BMP1 (By similarity).

Similarity:
Belongs to the lysyl oxidase family.

Database links:

Entrez Gene: 396474 Chicken

Entrez Gene: 4015 Human

Entrez Gene: 16948 Mouse

Entrez Gene: 24914 Rat

Omim: 153455 Human

SwissProt: Q05063 Chicken

SwissProt: P28300 Human

SwissProt: P28301 Mouse

SwissProt: P16636 Rat

Unigene: 102267 Human

Unigene: 172 Mouse

Unigene: 11372 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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