97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久国产欧美精品,sewang官网首页,狠狠躁18三区二区一区AI明星
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Progesterone Receptor/Gold Conjugated antibody (bs-23375R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-23375R-Gold
英文名稱 Rabbit Anti-Progesterone Receptor/Gold Conjugated antibody
中文名稱 膠體金標記的孕激素受體抗體
別    名 NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_HUMAN; Progestin receptor form A; Progestin receptor form B.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  免疫學  信號轉導  生長因子和激素  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Horse, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Progesterone Receptor
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.

Subunit:
Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.

Subcellular Location:
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.

Post-translational modifications:
Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.

Similarity:
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 5241 Human

Entrez Gene: 18667 Mouse

Entrez Gene: 100009094 Rabbit

Entrez Gene: 25154 Rat

Omim: 607311 Human

SwissProt: P06401 Human

SwissProt: Q00175 Mouse

SwissProt: P06186 Rabbit

SwissProt: Q63449 Rat

Unigene: 2905 Human

Unigene: 32405 Human

Unigene: 742403 Human

Unigene: 12798 Mouse

Unigene: 437703 Mouse

Unigene: 1947 Rabbit

Unigene: 10303 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 蜜桃视频在线观看一区 | 波多野结衣高潮喷水在线观看 | 亚洲韩国欧洲国产日产av | 日韩人妻无码AV一区二区三区 | 精品国产子伦久久久久久小说 | 男女啪啪免费观看网站 | 51国产偷自视频区视频免费的 | 18禁止导深夜福利备好纸巾 | 黄色高清在线观看 | 亚洲熟女色情网中文字幕 | 一边捏奶头一边高潮视频 | 亚洲爆乳中文字幕无码专区网站 | 巨波霸乳在线永久免费视频 | 色第一页| 亚洲国产精品成人一区二区 | 一级黄色片在线免费观看 | 人善交VIDEOS欧美3D | 亚洲AV无码AV男人的天堂不卡 | 亚洲色爱图小说专区 | 久久久久久久久久久美女 | 国产午夜av秒播在线观看 | 91草视频| 大地资源二在线观看官网 | 国产精品一区二区三区99 | 一区两区三区四区乱码国产精品 | JIZZJIZZ少妇亚洲水多 | 熟妇人妻无乱码中文字幕真矢织江 | 黄色毛片一级视频 | 色av网 | 91精品国产综合久久小仙女图片 | 久久青青草原一区二区 | 久久久久久久人妻无码中文字幕爆 | www.国产日本 | 在线观看免费网页欧美成 | 国产精品第100页 | 欧美va免费精品高清在线 | 日本老熟妇maturebbw | 亚洲欧美日韩综合在线丁香 | 91精品国产综合久久久亚洲 | 最好看的中文视频最好的中文 | av人摸人人人澡人人超碰小说 |