97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
人摸人人人澡人人超碰97,欧美二区视频,国产精品一区二区99
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Vinculin/PE-Cy5 Conjugated antibody (bs-23650R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-23650R-PE-Cy5
英文名稱 Rabbit Anti-Vinculin/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的粘著斑蛋白抗體
別    名 CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; OTTHUMP00000019861; OTTHUMP00000019862; VCL; VINC; VINC_HUMAN  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  信號轉導  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Vinculin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Function:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Subunit:
Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity). Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Metavinculin is muscle-specific.

Post-translational modifications:
Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques (By similarity).
Aceylated; mainly by myristic acid but also small amount of palmitic acid (By similarity).

DISEASE:
Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:611407]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in VCL are the cause of cardiomyopathy familial hypertrophic type 15 (CMH15) [MIM:613255]. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Similarity:
Belongs to the vinculin/alpha-catenin family.

Database links:

Entrez Gene: 7414 Human

Entrez Gene: 22330 Mouse

Entrez Gene: 305679 Rat

Omim: 193065 Human

SwissProt: P18206 Human

SwissProt: Q64727 Mouse

SwissProt: P85972 Rat

Unigene: 643896 Human

Unigene: 279361 Mouse

Unigene: 164613 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 一区视频免费观看 | 亚洲欧洲自拍拍偷无码 | 精品一区二区三区日本 | 亚洲国产成人精品无码区在线网站 | 日本亚洲国产黄www 香港三级日本三级韩国三级 | 亚洲欧洲成人在线 | 加山夏子av | 玩弄少妇肉体到高潮动态图 | 伊人夜色 | 成人免费看吃奶视频网站 | 前夜40集连续剧免费观看国语高清 | 1024久久| 午夜一级黄色大片 | 99毛片 | 免费黄色视屏 | 亚洲色偷偷av男人的天堂 | 67194中文字幕在线观看日韩 | av人摸人人人澡人人超碰小说 | 精品无码成人片一区二区 | 国产精品免费视频一区二区 | 国产精品天美传媒沈樵 | 亚洲熟女色情网中文字幕 | 天天爽一爽 | 伊人久久精品欧洲综合网 | 国产女同2互磨高潮在线观看 | jmcomic2最新安装包 | 国产美女视频a级做爰色戎 一本久久A精品一区二区 | 狠狠综合久久久久综合 | 高清性色生活片97 | 精品国产精品国产偷麻豆 | 玖色av| 日韩欧美一区二区三区四区 | 一级黄色录像影片夫妻性生活影片 | 久久中国精品 | 国产精品18久久久久久vr | 午夜影院在线午夜影院在线观看 | 国产精品视频麻豆 | 97精品人人A片免费看 | 国产精品2020| 欧产日产国产精品视频 | 欧美一级高清免费 |